Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic
Elnaz Harifi Mood, Lise Goltermann, Camilla Brolin, Lina Cavaco, Alireza Japoni-Nejad, Niloofar Yavari, Nicki Frederiksen, Henrik Franzyk, Peter E. Nielsen
Abstract
validation of the potentiation effect on both rifampicin and azithromycin treatment in a murine peritonitis model. Thus, CEP-136 is an interesting hit compound for further development of effective adjuvants for repurposing antibiotics for use against infections by multidrug-resistant Gram-negative bacteria.
Topics & Concepts
MicrobiologyAcinetobacter baumanniiAntibioticsColistinAntimicrobialBiologyBacteriaPeptidomimeticGram-negative bacteriaPseudomonas aeruginosaPathogenic bacteriaMultiple drug resistanceBacterial outer membraneEscherichia coliBiochemistryPeptideGeneticsGeneAntimicrobial Peptides and ActivitiesAntibiotic Resistance in BacteriaBacteriophages and microbial interactions