Clonally expanded, GPR15-expressing pathogenic effector T <sub>H</sub> 2 cells are associated with eosinophilic esophagitis
Duncan M. Morgan, Bert Ruiter, Neal P. Smith, Ang A. Tu, Brinda Monian, Brandon E. Stone, Navneet K. Virk-Hundal, Qian Yuan, Wayne G. Shreffler, J. Christopher Love
Abstract
T cells in patients with milk-triggered disease, suggesting that these cells are an expanded, food antigen-specific population with enhanced esophagus homing potential.
Topics & Concepts
Eosinophilic esophagitisBiologyImmunologyEsophagusPopulationAntigenT cellDiseasePathologyImmune systemMedicineAnatomyEnvironmental healthEosinophilic EsophagitisIL-33, ST2, and ILC PathwaysEosinophilic Disorders and Syndromes