SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride
Qian Zhao, Zhiyuan Tian, Guoyu Zhou, Qiang Niu, Jingwen Chen, Pei Li, Lixin Dong, Tao Xia, Shun Zhang, Aiguo Wang
Abstract
: Our data suggest the pivotal role of impaired mitochondrial biogenesis in developmental fluoride neurotoxicity and the underlying SIRT1 signaling dysfunction in such neurotoxic process, which emphasizes RSV as a potential therapeutic dietary agent for relieving developmental fluoride neurotoxicity.
Topics & Concepts
TFAMMitochondrial biogenesisNRF1MitochondrionCell biologyBiologyOrganelle biogenesisCoactivatormitochondrial fusionChemistryBiogenesisMitochondrial DNATranscription factorBiochemistryGeneFluoride Effects and RemovalAnesthesia and Neurotoxicity ResearchBone and Dental Protein Studies