Bioresponsive Hybrid Nanofibers Enable Controlled Drug Delivery through Glass Transition Switching at Physiological Temperature
Fei Pan, Altangerel Amarjargal, Stefanie Altenried, Mengdi Liu, Flavia Zuber, Zhihui Zeng, René M. Rossi, Katharina Maniura‐Weber, Qun Ren
Abstract
(34.8-36.5 °C). The "on"/"off" switch for controlled drug release can moreover be repeated at least 5 times. Furthermore, the fabricated nanofibrous membranes displayed a distinctive antibacterial activity, causing a log3 reduction of the viable cells for both Gram negative and positive pathogens at 37 °C, when the thermal switch was "on". This study forms the groundwork for a treatment concept where no external stimulus is needed for the release of antimicrobials at physiological conditions, and will help reduce the overuse of antibiotics by allowing controlled drug release.
Topics & Concepts
Glass transitionPolymerElectrospinningNanofiberMaterials scienceAntimicrobialControlled releaseMembraneMethacrylateChemical engineeringDrugNanotechnologyBiophysicsChemistryOrganic chemistryComposite materialPharmacologyBiochemistryMedicineBiologyEngineeringCopolymerElectrospun Nanofibers in Biomedical ApplicationsWound Healing and TreatmentsAntimicrobial agents and applications