Antibiotic resistance and drug modification: Synthesis, characterization and bioactivity of newly modified potent pleuromutilin derivatives with a substituted piperazine moiety
Yunpeng Yi, Shifa Yang, Yueyue Liu, Bin Yin, Zengcheng Zhao, Guiming Li, Zhongli Huang, Lei Chen, Fei Liu, Ruofeng Shang, Shuqian Lin
Topics & Concepts
Staphylococcus aureusChemistryAntibacterial activityIn vivoAntibioticsPiperazineMethicillin-resistant Staphylococcus aureusAntimicrobialMicrobiologyStaphylococcus epidermidisMoietyPharmacologyBacteriaStereochemistryBiochemistryBiologyOrganic chemistryGeneticsBiotechnologyVeterinary medicine and infectious diseasesPharmacological Effects of Natural CompoundsToxin Mechanisms and Immunotoxins