Intravenous bolus injection of fentanyl triggers an immediate central and upper airway obstructive apnea via activating vagal sensory afferents
Jianguo Zhuang, Xiuping Gao, Shan Shi, Fadi Xu
Abstract
Intravenous bolus injection of fentanyl triggers an immediate apnea, but the nature of apnea and relevant mechanisms remain unknown. Results in this study reveal that this fentanyl injection concurrently triggers an immediate central and upper airway obstructive apnea associated with chest wall rigidity via activating vagal sensory C-fibers.
Topics & Concepts
AnesthesiaMedicineFentanylApneaSuperior laryngeal nerveBronchoconstrictionAirwayInternal medicineStimulationObstructive Sleep Apnea ResearchCardiovascular Syncope and Autonomic DisordersRespiratory and Cough-Related Research