Chemical synthesis, inhibitory activity and molecular mechanism of 1-deoxynojirimycin–chrysin as a potent α-glucosidase inhibitor
Ran Zhang, Yueyue Zhang, Gaiqun Huang, Xiangdong Xin, Liumei Tang, Hao Li, Kwang Sik Lee, Byung Rae Jin, Zhongzheng Gui
Abstract
Hyperglycemia can be efficaciously regulated by inhibiting α-glucosidase activity and this is regarded as an effective strategy to treat type 2 diabetes.
Topics & Concepts
ChemistryChrysinNon-competitive inhibitionLipophilicityIC50Quenching (fluorescence)SulfamideLead compoundEnzymeBioavailabilityStereochemistryConjugateInhibitory postsynaptic potentialBiochemistryFluorescenceFlavonoidPharmacologyIn vitroOrganic chemistryAntioxidantBiologyNeurosciencePhysicsQuantum mechanicsMathematicsMathematical analysisNatural Antidiabetic Agents StudiesCarbohydrate Chemistry and SynthesisAdvanced Glycation End Products research