Age-specific differential changes on gut microbiota composition in patients with major depressive disorder
Jianjun Chen, Sirong He, Liang Fang, Bin Wang, Shunjie Bai, Jing Xie, Chanjuan Zhou, Wei Wang, Peng Xie
Abstract
were significantly decreased and increased, respectively, in middle-aged MDD patients as compared with middle-aged HCs. Meanwhile, six and 25 differentially abundant bacterial taxa responsible for the differences between MDD patients (young and middle-aged, respectively) and their respective HCs were identified. Our results demonstrated that there were age-specific differential changes on gut microbiota composition in patients with MDD. Our findings would provide a novel perspective to uncover the pathogenesis underlying MDD.
Topics & Concepts
BacteroidetesFirmicutesGut floraMajor depressive disorderFecesActinobacteriaPhysiologyInternal medicineMedicineProteobacteriaBiologyGastroenterologyImmunologyEcologyBacteria16S ribosomal RNAGeneticsAmygdalaGut microbiota and healthTryptophan and brain disordersDiet and metabolism studies