De Novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining
You Song, Li Xie, YeonKyeong Lee, Knut Erik Tollefsen
Abstract
data to predefined models. A complete workflow for assembly and evaluation of qAOPs has been presented, which may serve as a good example for future de novo qAOP development for chemical and nonchemical stressors.
Topics & Concepts
Adverse Outcome PathwayDaphnia magnaWorkflowStressorBioassayBiologyComputational biologyUltraviolet radiationComputer scienceEcologyToxicityChemistryDatabaseNeuroscienceRadiochemistryOrganic chemistryEnvironmental Toxicology and EcotoxicologyComputational Drug Discovery MethodsInsect Resistance and Genetics