HSA-templated self-generation of gold nanoparticles for tumor vaccine delivery and combinational therapy
Dan Zhang, Pengran Liu, Xianya Qin, Lu Cheng, Fuqian Wang, Xin Xiong, Chuanqi Huang, Zhiping Zhang
Abstract
studies demonstrated that the nanoparticles can mediate light-to-heat transduction under near-infrared irradiation (NIR), achieving tumor ablation and enhancing antitumor immunity. Our design can insulate toxic agents, streamline flux, increase the transition efficiency of interactants and improve the product yield, contributing a novel modality for facile and green synthesis of nanovaccines.
Topics & Concepts
Photothermal therapyHuman serum albuminColloidal goldIn vivoMaterials scienceNanoparticleNanotechnologyTransduction (biophysics)PeptideBiophysicsDrug deliveryChemistryBiochemistryBiologyBiotechnologyNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery