Flavonoids from <i>Eucommia ulmoides</i> and their <i>in vitro</i> hepatoprotective activities
Weixing Huang, Liqin Ding, Nan Zhang, Wei Li, Kazuo Koike, Feng Qiu
Abstract
A phytochemical investigation of the barks of Eucommia ulmoides Oliv. resulted in the isolation of 18 flavonoids (1-18). The new compound, eucommiaflavone (1) was structurally elucidated by various spectroscopic analyses. In particular, Mo2(OAc)4-induced circular dichroism (ICD) analysis was applied to determine the absolute configuration of 1. Furthermore, five flavonoids (4, 9, 11, 13, and 15) revealed significant in vitro hepatoprotective activity against D-galactosamine-induced cytotoxicity in human hepatoma HepG2 cells.
Topics & Concepts
Eucommia ulmoidesPhytochemicalChemistryTraditional medicineCytotoxicityIn vitroStereochemistryBiochemistryMedicineAlternative medicinePathologyTraditional Chinese medicinePhytochemistry and Biological ActivitiesNatural product bioactivities and synthesisPlant-derived Lignans Synthesis and Bioactivity