Recent Advances in Ablative Therapies for Hepatocellular Carcinoma
Summan Zahra, Ammarah Nadeem, Ashima Kundu, Nick Gibson, Ali Haggaz, Kent T. Sato, Robert J. Lewandowski, Andrew C. Gordon
Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with curative surgical interventions feasible for a minority of patients. This review highlights recent advances in thermal (e.g., radiofrequency ablation, microwave ablation, and cryoablation) and nonthermal (e.g., ethanol ablation and irreversible electroporation) ablative modalities as curative-intent alternatives to surgery. Evolving applications of transcatheter intra-arterial radioembolization (TARE) with ablative dosimetry will be explored, and histotripsy, an emerging technology, will be introduced.
Topics & Concepts
Ablative caseHepatocellular carcinomaMedicineThermal ablationRadiofrequency ablationMicrowave ablationTreatment modalityPercutaneous ethanol injectionRadiologyAblationTherapeutic modalitiesOncologyModalitiesCancer researchRadiation therapyCatheter ablationCarcinomaTumor ablationCurative treatmentMicrosphereHepatocellular Carcinoma Treatment and PrognosisRenal cell carcinoma treatmentCatalytic Processes in Materials Science