Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer
Xin Wen, Shui Liu, Jiyao Sheng, Manhua Cui
Abstract
-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.
Topics & Concepts
Cervical cancerCisplatinBiologyLong non-coding RNAResistance (ecology)Computational biologyCancerBioinformaticsMedicineGeneticsRNAGeneEcologyChemotherapyCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation