Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
Jan W. Buikema, Soah Lee, William R. Goodyer, Renée G. C. Maas, Orlando Chirikian, Guang Li, Yi Miao, Sharon L. Paige, Daniel Lee, Haodi Wu, David T. Paik, Siyeon Rhee, Lei Tian, Francisco X. Galdos, Nazan Puluca, Benjamin Beyersdorf, James B. Hu, Aimee Beck, Sneha Venkamatran, Srilatha Swami, Paul J.M. Wijnker, Maike Schuldt, L. M. Dorsch, Alain van Mil, Kristy Red-Horse, Joy Y. Wu, Caroline Geisen, Michael Hesse, Vahid Serpooshan, Stefan Jovinge, Bernd K. Fleischmann, Pieter A. Doevendans, Jolanda van der Velden, K. Christopher García, Joseph C. Wu, Joost P. G. Sluijter, Sean M. Wu
Topics & Concepts
GSK-3Wnt signaling pathwayCell biologyBiologyInduced pluripotent stem cellCell growthContact inhibitionCellProtein kinase BSignal transductionPhosphorylationHippo signaling pathwayGlycogen synthaseBiochemistryEmbryonic stem cellGenePluripotent Stem Cells ResearchCongenital heart defects researchTissue Engineering and Regenerative Medicine