Ru-NHC-Catalyzed Asymmetric, Complete Hydrogenation of Indoles and Benzofurans: One Catalyst with Dual Function
Fuhao Zhang, Himadri Sekhar Sasmal, Constantin G. Daniliuc, Frank Glorius
Abstract
The highly enantioselective and complete hydrogenation of protected indoles and benzofurans has been developed, affording facile access to a range of chiral three-dimensional octahydroindoles and octahydrobenzofurans, which are prevalent in many bioactive molecules and organocatalysts. Remarkably, we are in control of the nature of the ruthenium N-heterocyclic carbene complex and employed the complex as both homogeneous and heterogeneous catalysts, providing new avenues for its potential applications in the asymmetric hydrogenation of more challenging aromatic compounds.
Topics & Concepts
ChemistryCatalysisCarbeneRutheniumEnantioselective synthesisAsymmetric hydrogenationHomogeneousCombinatorial chemistryOrganic chemistryHomogeneous catalysisDual roleMoleculePhysicsThermodynamicsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry