Segmental NELL-1 Membranous Nephropathy Complicating Tiopronin Therapy
Dominick Santoriello, Ravi Ramaswamy, Satoru Kudose, Glen S. Markowitz
Abstract
Neural epidermal growth factor-like 1 protein (NELL-1) was first identified as a membranous antigen by Sethi et al.1 utilizing laser capture microdissection and mass spectrometry followed by immunostaining. NELL-1 is currently the most common non-phospholipaseA2 receptor (PLA2R) membranous antigen. Segmental membranous changes are well-described in NELL-1 membranous nephropathy (MN).2 NELL-1 MN has been linked to malignancy, use of traditional indigenous medicines, and lipoic acid (LA) supplementation, among other conditions.
Topics & Concepts
Membranous nephropathyMedicineImmunostainingMalignancyPathologyLaser capture microdissectionImmunohistochemistryInternal medicineGlomerulonephritisKidneyBiologyBiochemistryGeneGene expressionBiochemical Acid Research StudiesAmino Acid Enzymes and MetabolismBiomedical Research and Pathophysiology