Electrochemical Enaminone-Thioamide Annulation and Thioamide Dimeric Annulation for the Tunable Synthesis of Thiazoles and 1,2,4-Thiadiazole
Qihui Huang, Jianchao Liu, Jie‐Ping Wan
Abstract
A green and sustainable electrochemical oxidative cyclization of enaminones with thioamides under metal- and oxidant-free conditions has been developed, providing an efficient approach for thiazole synthesis. Furthermore, 1,2,4-thiadiazoles can be selectively accessed via the electrochemical dimerization of thioamides in the absence of enaminones.
Topics & Concepts
ThioamideChemistryThiazoleAnnulationElectrochemistryThiadiazolesCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisElectrodePhysical chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions