A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia
Isabella Quinti, Vassilios Lougaris, Cinzia Milito, Francesco Cinetto, Antonio Pecoraro, Ivano Mezzaroma, Claudio Maria Mastroianni, Ombretta Turriziani, Maria Pia Bondioni, Matteo Filippini, Annarosa Soresina, Giuseppe Spadaro, Carlo Agostini, Rita Carsetti, Alessandro Plebani
Abstract
COVID-19 had a mild clinical course in patients with Agammaglobulinemia lacking B lymphocytes, whereas it developed aggressively in Common Variable Immune Deficiency. Our data offer mechanisms for possible therapeutic targets.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Virology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MedicineInternal medicineOutbreakDiseaseInfectious disease (medical specialty)Immunodeficiency and Autoimmune DisordersChronic Lymphocytic Leukemia ResearchBlood groups and transfusion