GWAS significance thresholds for deep phenotyping studies can depend upon minor allele frequencies and sample size
Huma Asif, Ney Alliey‐Rodriguez, Sarah Keedy, Carol A. Tamminga, John A. Sweeney, Godfrey D. Pearlson, Brett A. Clementz, Matcheri S. Keshavan, P.F. Buckley, Chunyu Liu, Benjamin M. Neale, Elliot S. Gershon
Topics & Concepts
Minor allele frequencyBonferroni correctionSample size determinationSingle-nucleotide polymorphismPermutation (music)Multiple comparisons problemGeneticsMathematicsGenome-wide association studyShufflingStatisticsBiologyCombinatoricsGenotypeAlgorithmGenePhysicsAcousticsGenetic Associations and EpidemiologyGene expression and cancer classificationGenetic Mapping and Diversity in Plants and Animals