Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency
Nada Ibrahim, Pascal Bonnet, Jean‐Daniel Brion, Jean‐François Peyrat, Jérôme Bignon, Hélène Levaïque, Béatrice Josselin, Thomas Robert, Pierre Colas, Stéphane Bach, Samir Messaoudi, Mouâd Alami, Abdallah Hamzé
Topics & Concepts
ChemistryThioetherStereochemistryKinaseCytotoxic T cellStructure–activity relationshipAmine gas treatingIn vitroDocking (animal)CytotoxicityIn silicoBiochemistryOrganic chemistryNursingMedicineGeneBiochemical and Molecular ResearchHIV/AIDS drug development and treatmentSynthesis and biological activity