The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity
Inna G. Ovsyannikova, Iana H. Haralambieva, Stephen N. Crooke, Gregory A. Poland, Richard B. Kennedy
Abstract
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyVirologyImmune system2019-20 coronavirus outbreakBetacoronavirusGeneticsHost (biology)ImmunologyImmune escapeHost responseMedicineDiseaseInfectious disease (medical specialty)PathologyOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19