Association between Cervical Microbiota and HPV: Could This Be the Key to Complete Cervical Cancer Eradication?
Eliano Cascardi, Gerardo Cazzato, Antonella Daniele, Erica Silvestris, Gennaro Cormio, Giovanni Di Vagno, Antonio Malvası, Vera Loizzi, Salvatore Scacco, Vincenzo Pinto, Ettore Cicinelli, Eugenio Maiorano, Giuseppe Ingravallo, Leonardo Resta, Carla Minoia, Miriam Dellino
Abstract
The heterogeneity of the cervico-vaginal microbiota can be appreciated in various conditions, both pathological and non-pathological, and can vary according to biological and environmental factors. Attempts are still in course to define the interaction and role of the various factors that constitute this community of commensals in immune protection, inflammatory processes, and the onset of precancerous lesions of the cervical epithelium. Despite the many studies on the relationship between microbiota, immunity, and HPV-related cervical tumors, further aspects still need to be probed. In this review article, we will examine the principal characteristics of microorganisms commonly found in cervico-vaginal specimens (i) the factors that notoriously condition the diversity and composition of microbiota, (ii) the role that some families of organisms may play in the onset of HPV-dysplastic lesions and in neoplastic progression, and (iii) possible diagnostic-therapeutic approaches.