Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies
Weng M. Ng, Sahin Mehmet, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Abstract
. Structural characterization of two of these antibodies indicates that antibody recognition likely interferes with GP1-mediated recognition of the transferrin receptor 1. These data provide molecular-level detail for a key region of vulnerability on the New World arenavirus surface and a blueprint for therapeutic antibody development.
Topics & Concepts
Monoclonal antibodyNeutralizationVirologyArenavirusImmunizationAntibodyImmunologyBiologyLymphocytic choriomeningitisVirusAntigenCD8Viral Infections and Outbreaks ResearchViral gastroenteritis research and epidemiologyHepatitis B Virus Studies