Intricate Metabolic Network for Paclitaxel Biosynthesis
Yuanwei Gou, Xiaojing Jiang, Jiazhang Lian
Abstract
species, probably due to differences in partner proteins or cellular microenvironments. Further elucidation of biosynthesis mechanisms, including the reaction order and the promiscuity of key enzymes, is anticipated through collaborative efforts among botanists, chemists, and synthetic biologists.
Topics & Concepts
BiosynthesisPaclitaxelEnzymeBiochemistryTaxusCytochrome P450AcetylationComputational biologyHeterologous expressionChemistryBiologyGeneGeneticsCancerBotanyRecombinant DNAMicrobial Natural Products and BiosynthesisCancer Treatment and PharmacologyPlant biochemistry and biosynthesis