Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana
Karunakaran Kalesh, Sandeep Sundriyal, Hirunika Perera, Steven L. Cobb, Paul W. Denny
Abstract
Leishmania spp. are the causative agents of leishmaniasis, a poverty-related disease, which is endemic in >90 countries worldwide, affecting approximately 12 million people, with an estimated 700,000 to 1 million new cases and around 70,000 deaths annually. Inhibitors of the chaperone protein Hsp90 have shown promising antileishmanial activity.
Topics & Concepts
Leishmania mexicanaHsp90ProteomeProtein biosynthesisHeat shock proteinHsp90 inhibitorBiologyBiochemistryQuantitative proteomicsProteomicsRibosomal proteinChemistryRibosomeLeishmaniaRNAParasite hostingWorld Wide WebGeneComputer scienceHeat shock proteins researchResearch on Leishmaniasis StudiesInsect and Pesticide Research