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SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS

Gabriel Linares, Yichen Li, Wen-Hsuan Chang, Jasper Rubin-Sigler, Stacee Mendonca, Sarah Hong, Yunsun Eoh, Wenxuan Guo, Yi‐Hsuan Huang, Jonathan Chang, Sharon Tu, Nomongo Dorjsuren, Manuel Santana, Shu‐Ting Hung, Johnny Yu, Joscany Perez, Michael Chickering, Tze-Yuan Cheng, Chi‐Chou Huang, Shih-Jong James Lee, Hao-Jen Deng, Kieu‐Tram Bach, Kamden Gray, Vishvak Subramanyam, Jeffrey Rosenfeld, Samuel V. Alworth, Hani Goodarzi, Justin K. Ichida

2023Cell stem cell28 citationsDOIOpen Access PDF

Topics & Concepts

Amyotrophic lateral sclerosisC9orf72NeurodegenerationBiologySpliceosomeNeuroscienceDiseasePhenotypeSOD1Motor neuronBioinformaticsGeneGeneticsMedicineRNA splicingTrinucleotide repeat expansionRNAPathologySpinal cordAlleleAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchRNA Research and Splicing
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS | Litcius