A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze‐Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz
Abstract
Innate-like human type 3 effector γδ T cells with canonical Vγ9Vδ2 + TCR develop in the earliest fetal thymus and persist into adulthood.
Topics & Concepts
EffectorBiologyDiversity (politics)FetusT-cell receptorImmunologyCell biologyType (biology)EcologyPregnancyT cellGeneticsImmune systemSociologyAnthropologyImmune Cell Function and InteractionT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics