An Organic Nanotherapeutic Agent Self‐Assembled from Cyanine and Cu (II) for Combined Photothermal and Chemodynamic Therapy
Xiaojing Li, Dongmei Xi, Mingwang Yang, Wen Sun, Xiaojun Peng, Jiangli Fan
Abstract
Abstract Although the combination of photothermal/chemodynamic therapy (PTT/CDT) based on various inorganic nanomaterials has promising anticancer effects, poor biocompatibility and biodegradability of inorganic nanoplatforms pose obstacles to their use in clinic. On the contrary, nanoscale metal−organic particles are considered to be a promising platform because of their biocompatibility and efficient metabolism. Herein, HA@Cy‐Cu NPs are prepared using the coordination‐driven assembly of cyanine dyes with Cu 2+ ions. HA@Cy‐Cu NPs demonstrate excellent synergistic PTT/CDT, a high photothermal conversion efficiency (43%), and enhanced photostability. Moreover, Cu 2+ in the NPs can be reduced to Cu + by glutathione (GSH) and can transform H 2 O 2 to •OH, which down‐regulates intracellular GSH levels and up‐regulates significant oxidative damage. Therefore, promising in vivo tumor ablation is observed at a low dose of HA@Cy‐Cu, suggesting that the combination of PTT/CDT greatly improved the antitumor performance. HA@Cy‐Cu can further improve organic nano‐systems for anti‐tumor therapy by integrating PTT and CDT.