Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors
Changbin Jing, Cong Fu, Nicole Prutsch, Meng Wang, Shuning He, A. Thomas Look
Topics & Concepts
Progenitor cellHaematopoiesisCancer researchBiologyStem cellPARP1PharmacologyCell biologyPoly ADP ribose polymeraseGeneticsDNAPolymeraseAcute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation