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Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription

Dongfang Wang, Keai Sinn Tan, Weiping Zeng, Sixu Li, Yueqi Wang, Fapeng Xu, Wen Tan

2022Life Sciences15 citationsDOI

Topics & Concepts

LDL receptorMAPK/ERK pathwayInternal medicineEndocrinologyChemistrySignal transductionCell biologyBiologyCholesterolLipoproteinMedicineCancer-related gene regulationPhosphodiesterase function and regulationEpigenetics and DNA Methylation
Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription | Litcius