Advances in the Relationship Between Regulator of Ribosome Synthesis 1 (RRS1) and Diseases
Yanan Hua, Jinlian Song, Cuixiu Peng, Runze Wang, Zhongliang Ma, Jinyu Zhang, Zheng Zhang, Ning Li, Lin Hou
Abstract
A regulator of ribosome synthesis 1 (RRS1) was discovered in yeast and is mainly localized in the nucleolus and endoplasmic reticulum. It regulates ribosomal protein, RNA biosynthesis, and protein secretion and is closely involved in cellular senescence, cell cycle regulation, transcription, translation, oncogenic transformation etc., Mutations in the RRS1 gene are associated with the occurrence and development of Huntington's disease and cancer, and overexpression of RRS1 promotes tumor growth and metastasis. In this review, the structure, function, and mechanisms of RRS1 in various diseases are discussed.
Topics & Concepts
NucleolusRegulatorRibosomeBiologyCell biologyRibosome biogenesisProtein biosynthesisEndoplasmic reticulumTranslation (biology)5.8S ribosomal RNARibosomal proteinGeneRNAGeneticsMessenger RNACytoplasmRNA modifications and cancerDNA Repair MechanismsUbiquitin and proteasome pathways