Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease
Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang, Haibing Zhang
Abstract
mice are profoundly inhibited by additional deletion of Ripk1. Taken together, these results reveal a previously unidentified physiological function of RHIM of RIPK3 in regulating RIPK1-dependent cell death and lymphoproliferative disease.
Topics & Concepts
RIPK1NecroptosisFADDProgrammed cell deathCell biologyKinaseBiologyProtein kinase domainCancer researchApoptosisCaspaseMutantBiochemistryGeneCell death mechanisms and regulationPhagocytosis and Immune Regulationinterferon and immune responses