Dual role of exosomal circCMTM3 derived from GSCs in impeding degradation and promoting phosphorylation of STAT5A to facilitate vasculogenic mimicry formation in glioblastoma
Chengbin Wang, Yingliang Liu, Zhenxing Zuo, Daming Cui, Yuzhen Xu, Li Li, Yangfu Jiang
Abstract
Exosomal circCMTM3 possessing growth factor-mimetic property activates the JAK2/STAT5A pathway via non-canonical manner, and promotes VM formation in GBM. The molecular communications between GSCs and DGCs offers a therapeutic strategy for targeting the neovascularization of GBM.
Topics & Concepts
Vasculogenic mimicryGlioblastomaPhosphorylationMimicryCancer researchDual (grammatical number)Cell biologyMicrovesiclesChemistryBiologymicroRNABiochemistryCancerGeneticsMetastasisEcologyArtLiteratureGeneCircular RNAs in diseasesMicroRNA in disease regulationExtracellular vesicles in disease