Network Pharmacology-Based Analysis on the Action Mechanism of Oleanolic Acid to Alleviate Osteoporosis
Yi Wu, Lijie Gao, Yingsai Fan, Ye Chen, Qin Li
Abstract
model. Altogether, our study elucidated the candidate targets for OA to alleviate OP, explored the protein-protein interactions and related signaling pathways of the targets, and validated the anti-OP effects of OA. It could provide a better understanding of the action mechanism in OA to treat OP.
Topics & Concepts
Mechanism (biology)Oleanolic acidMechanism of actionPharmacologyAction (physics)OsteoporosisChemistryComputational biologyNeuroscienceMedicinePsychologyBiologyBiochemistryInternal medicineEpistemologyAlternative medicinePhilosophyPhysicsPathologyIn vitroQuantum mechanicsBone Metabolism and DiseasesInflammatory mediators and NSAID effectsNatural product bioactivities and synthesis