Huntingtin-interacting protein family members have a conserved pro-viral function from <i>Caenorhabditis elegans</i> to humans

Abstract

Significance Understanding host–virus interaction mechanisms is critical to identify novel drug targets for development of antiviral therapeutics. The C. elegans –Orsay virus infection system offers an innovative approach for discovering host factors required for virus infection. The hipr-1 gene was determined to be essential in C. elegans for Orsay virus infection at an early stage of the virus life cycle. Studies of its orthologs in human cell culture determined that both HIP1 and HIP1R are important for Coxsackie B3 virus infection, highlighting the evolutionarily conserved role of HIP-family proteins in virus infection from nematodes to humans.

Topics & Concepts