Methylation-dependent MCM6 repression induced by LINC00472 inhibits triple-negative breast cancer metastasis by disturbing the MEK/ERK signaling pathway
Guoli Shao, Xulong Fan, Pusheng Zhang, Xuewen Liu, Lei Huang, Shufeng Ji
Abstract
experiments further substantiated that overexpression of LINC00472 inhibited tumor growth and metastasis to lungs by decreasing the expression of MCM6. Overall, the present study demonstrated that LINC00472-mediated epigenetic silencing of MCM6 contributes to the prevention of tumorigenesis and metastasis in TNBC, providing an exquisite therapeutic target for TNBC.
Topics & Concepts
MAPK/ERK pathwayCancer researchTriple-negative breast cancerBreast cancerMethylationPsychological repressionMetastasisSignal transductionInternal medicineOncologyMedicineBiologyCancerCell biologyGeneticsGeneGene expressionCancer-related molecular mechanisms researchRNA modifications and cancerMolecular Biology Techniques and Applications