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Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo

Seiji Miyauchi, Soojin Kim, Wooin Lee, Yuichi Sugiyama

2021Pharmacology & Therapeutics27 citationsDOI

Topics & Concepts

AlbuminIn vivoChemistryPharmacologyDrug metabolismIn vitroSerum albuminEffluxPlasma protein bindingDrugBiochemistryMetabolismMedicineBiologyBiotechnologyDrug Transport and Resistance MechanismsProtein Interaction Studies and Fluorescence AnalysisAntibiotics Pharmacokinetics and Efficacy
Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo | Litcius