DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation
Ruining Ma, Lina Ma, Weiji Weng, Yingping Wang, Huiqing Liu, Rongjun Guo, Yingwei Gao, Jun Tu, Tian‐Le Xu, Jinke Cheng, Michael X. Zhu, Aiwu Zhou, Yong Li
Abstract
mutant, protected cells from apoptosis. Thus, DUSP6 exerts a cytoprotective role by directly dephosphorylating Drp1-S616, which is disrupted by deSUMOylation under oxidation.
Topics & Concepts
DephosphorylationSUMO proteinPhosphorylationDUSP6Cell biologyApoptosisPhosphataseMitochondrionKinaseUbiquitinBiologyMitochondrial fissionChemistryMolecular biologyBiochemistryProtein phosphatase 2GeneUbiquitin and proteasome pathwaysMitochondrial Function and PathologyATP Synthase and ATPases Research