Photoprotective effects of sweet potato leaf polyphenols and caffeic acid against UV-induced skin-damage in BALB/C nude mice
Jingyang Hong, Taihua Mu, Hongnan Sun, Christophe Blecker, Aurore Richel
Abstract
most significantly inhibited the dermal thickening, increased the activities of the superoxide dismutase, catalase as well as glutathione peroxidase, and decreased the content of serum MDA and protein carbonyls markedly. Furthermore, the topical SPLP suppressed the UV-induced rise in the inflammatory markers MMP-1, TNF-α, and NF-κB, and alleviated phosphorylation levels of the stress-signaling proteins JNK and p38. Thus, topical SPLP provided the best overall protection for mouse skin from UV-induced damage.
Topics & Concepts
Superoxide dismutaseChemistryMalondialdehydeHydroxyprolineEpidermis (zoology)CatalaseDermisCaffeic acidBiochemistryOxidative stressGlutathione peroxidaseHairlessPharmacologyAntioxidantMolecular biologyBiologyMedicinePathologyAnatomySkin Protection and Agingmelanin and skin pigmentationAntioxidant Activity and Oxidative Stress