Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases
Shu‐Yi Liao, Shaikh M. Atif, Kara J. Mould, Iain R. Konigsberg, Rui Fu, Elizabeth Davidson, Li Li, Andrew P. Fontenot, Lisa A. Maier, Ivana V. Yang
Abstract
<b>scRNA-seq characterised macrophage transcriptional and chromatin accessibility profiles in BAL cells in granulomatous lung diseases, chronic beryllium disease and sarcoidosis, and identified signatures of disease progression in sarcoidosis.</b>https://bit.ly/3piFIBy
Topics & Concepts
SarcoidosisMacrophageChromatinRNADiseaseBiologyChronic granulomatous diseaseImmunologyGeneMedicinePathologyGeneticsIn vitroIL-33, ST2, and ILC PathwaysSarcoidosis and Beryllium Toxicity ResearchExtracellular vesicles in disease