Photoinduced Three-Component Difluoroalkylation of Quinoxalinones with Alkenes via Difluoroiodane(III) Reagents
Ningning Zhou, Ruiyue Liu, Chunmeng Zhang, Kun Wang, Jiaxu Feng, Xia Zhao, Kui Lu
Abstract
An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine(III) reagents is disclosed. The new designed difluoroiodane(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxaline-2(1H)-ones in moderate to excellent yields under mild conditions. Experimental studies demonstrated that a difluoroalkyl radical intermediate was involved in this reaction.
Topics & Concepts
Hypervalent moleculeReagentChemistryReactivity (psychology)Environmentally friendlyIodineQuinoxalineCombinatorial chemistryComponent (thermodynamics)Organic chemistryBiologyAlternative medicineMedicineThermodynamicsPathologyPhysicsEcologyFluorine in Organic ChemistrySynthesis and Biological EvaluationOxidative Organic Chemistry Reactions