DNA/Protein Binding and Apoptotic-Induced Anticancer Property of a First Time Reported Quercetin–Iron(III) Complex Having a Secondary Anionic Residue: A Combined Experimental and Theoretical Approach
Manjushree Bera, Manik Das, Malay Dolai, Soumik Laha, Md. Maidul Islam, Bidhan Chandra Samanta, Arindam Das, Indranil Choudhuri, Nandan Bhattacharyya, Tithi Maity
Abstract
to display significant anticancer properties. Finally, by using the AO/PI staining approach, the apoptotic-induced cell-killing mechanism as well as the detection of cell morphological changes has been confirmed.
Topics & Concepts
ChemistryElectron paramagnetic resonanceMacromoleculeQuenching (fluorescence)TitrationCrystallographyHuman serum albuminDNAStereochemistryFluorescenceBiochemistryInorganic chemistryNuclear magnetic resonancePhysicsQuantum mechanicsProtein Interaction Studies and Fluorescence AnalysisMetal complexes synthesis and propertiesFree Radicals and Antioxidants