Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus
Seungjoon Kim, Hyeonho Kim, Dongseok Park, Jinhu Kim, Joohyeon Hong, Jae Seong Kim, Hyeji Jung, Dong‐Wook Kim, Eunji Cheong, Jaewon Ko, Ji Won Um
Abstract
receptor complexes with ARF-dependent pathways to prevent aberrant, runaway excitation and thereby contributes to the integrity of SST interneurons and proper GABAergic synapse maintenance.
Topics & Concepts
GABAergicHippocampusSynapseSomatostatinNeuroscienceBiologySynapse formationInternal medicineCell biologyChemistryEndocrinologyInhibitory postsynaptic potentialMedicineNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersIon Transport and Channel Regulation