A cysteine-selective fluorescent probe for monitoring stress response cysteine fluctuations
Yang Yang, Liangwei Zhang, Liangwei Zhang, Xia Zhang, Shudi Liu, Yue Wang, Li Zhang, Li Zhang, Zhuo Ma, Huiyan You, Lingxin Chen
Abstract
Rare studies provided evidence for the real-time monitoring of stress response cysteine fluctuations. Here, we have successfully designed and synthesized a cysteine-selective fluorescent probe 1 to monitor stress response Cys fluctuations, providing visual evidence of Hg2+ regulated cysteine fluctuations for the first time, which may open a new way to help researchers to reveal the mechanism of heavy metal ion poisoning.
Topics & Concepts
CysteineFluorescenceChemistryBiophysicsBiochemistryBiologyOpticsPhysicsEnzymeSulfur Compounds in BiologyMolecular Sensors and Ion DetectionCarbon and Quantum Dots Applications