Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice
Élisabeth Walsh‐Wilkinson, Mohamed Lamine Aidara, Audrey Morin-Grandmont, Sara-Ève Thibodeau, Juliette Gagnon, Mathieu Genest, Marie Arsenault, Jacques Couët
Abstract
We propose a new method for the study of regional strain data by analyzing individually the software-generated 48 regions of interest (ROI) from an LV wall tracing in B-mode. This helps obtain a more comprehensive profile of strain data. Using these new tools, we studied in mice how sex, sex hormones, age, or a pathological stress influenced strain parameters. We show that for similar cardiac hypertrophy, regional strain shows important differences related to sex, sex hormones, and age.
Topics & Concepts
Internal medicineVentricleEndocrinologyEndocardiumMuscle hypertrophyAngiotensin IIMedicineEjection fractionStrain (injury)Left ventricular hypertrophyHeart failureBlood pressureCardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsCardiac Valve Diseases and Treatments