Molecular locker probe enrichment of gene fusion variants from matched patient liquid biopsy specimens for magneto-bioelectrocatalytic nanosensing
Kevin M. Koo, Matt Trau
Abstract
copies) was achieved with enhanced 10 copies (zmol) detection limit. With the combination of locker probe enrichment and magneto-bioelectrocatalytic cycling readout for NA mutant variant analysis, the potential of non-invasive liquid biopsies may be exploited for the benefit of cancer patients.
Topics & Concepts
MutantFusion geneLiquid biopsyGeneCancerBiopsyFusionChemistryCancer researchMaterials scienceBiologyMedicinePathologyGeneticsBiochemistryLinguisticsPhilosophyAdvanced biosensing and bioanalysis techniquesMolecular Biology Techniques and ApplicationsCancer Genomics and Diagnostics