Systems for in vivo hypermutation: a quest for scale and depth in directed evolution
Gordon Rix, Chang C. Liu
Topics & Concepts
Somatic hypermutationScale (ratio)BiologySequence spaceDirected evolutionSequence (biology)Computational biologyIn vivoBiological evolutionEvolutionary biologyComputer scienceGeneticsGeneMathematicsGeographyB cellAntibodyMutantPure mathematicsBanach spaceCartographyEvolution and Genetic DynamicsCRISPR and Genetic EngineeringEvolutionary Algorithms and Applications