Mussel-inspired adhesive gelatin–polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration
Yamei Wang, Dongdong Xiao, Lin Quan, Hongbin Chai, Xiaofeng Sui, Bijia Wang, Hong Xu, Zhiping Mao
Abstract
. Finally, a rat full-thickness skin defect wound model was used to evaluate the performance of the hydrogels in wound repair. The hydrogel group showed a significantly reduced wound area (95.72%) compared with the blank group (86.34%) on day 14. The hydrogel promoted the collagen deposition, weakened the inflammatory response and enhanced wound healing. Therefore, the hydrogel with multifunctional properties is a promising candidate for complete skin regeneration.
Topics & Concepts
GelatinTetracycline HydrochlorideSelf-healing hydrogelsAdhesiveWound healingPolyacrylamideAntibacterial activityRegeneration (biology)Materials scienceBiomedical engineeringTetracyclineChemistryComposite materialPolymer chemistrySurgeryAntibioticsMedicineBacteriaOrganic chemistryBiochemistryGeneticsLayer (electronics)BiologyCell biologyWound Healing and TreatmentsSurgical Sutures and AdhesivesPolymer Surface Interaction Studies