Conditional ablation of DIS3L2 ribonuclease in pre-meiotic germ cells causes defective spermatogenesis and infertility in male mice
Nana Li, Junjie Yu, Yanqin Feng, Phoebe Xu, Xiao Wang, Meiyang Zhou, Hong Li, Yu Xu, Zhengpin Wang
Abstract
Collectively, these findings highlight the critical role of DIS3L2 ribonuclease-mediated RNA degradation in safeguarding the correct transcriptome during spermatogonial differentiation and spermatocyte meiotic progression, thus ensuring normal spermatogenesis and male fertility.
Topics & Concepts
SpermatogenesisRibonucleaseMeiosisAndrologyGermInfertilityMale infertilityBiologyAblationGermlineMicroinjectionCell biologyMedicineGeneticsInternal medicineRNAPregnancyGeneDNA Repair Mechanisms