Synthesis, Characterization, and Cytotoxicity of New Spirooxindoles Engrafted Furan Structural Motif as a Potential Anticancer Agent
Mezna Saleh Altowyan, Saied M. Soliman, Matti Haukka, Nora Hamad Al‐Shaalan, Aminah A. Alkharboush, Assem Barakat
Abstract
as a dual inhibitor of EGFR/CDK-2 proteins, and this may highlight the molecular targets for its cytotoxic activity.
Topics & Concepts
ChemistryMoietyFuranStereochemistryIC50ArylCytotoxicityIn vitroBiochemistryOrganic chemistryAlkylSynthesis and Biological EvaluationSynthesis and biological activityOrganic Chemistry Cycloaddition Reactions